Deprilium®
Natural improvement of psycho-emotional state
1 capsule contains:
- S-adenosyl-L-methionine – 200 mg
- L- methylfolate – 0,4 mg, equivalent to 0,4 mg of folic acid
- Vitamin B12 as methylcobalamin – 250 µg
Pack size:
30 capsules
DEPRILIUM®:
- Has a moderate antidepressant effect
- Regulates the metabolism of neurotransmitters
- Improves cognitive function and performance
- Demonstrates neuroprotective properties
- Has a good safety profile
Recommendations for use:
Depressive syndrome associated with
- Depressed mood
- Apathy
- Easy fatigability
- Low self-esteem
- Decreased working ability and cognitive function
DEPRILIUM® contains a scientifically proven combination of natural substances that normalizes the psycho-emotional state by improving the metabolism of neurotransmitters in the brain resulting in the relief of such manifestations as depressed mood, apathy, easy fatigability, low self-esteem, etc.; improved mood and well-being; increased working ability and concentration; improved cognitive functions.
S-adenosyl-L-methionine, SAMe, is a natural substance found in all cells of the body that is involved in more than 200 metabolic processes. Numerous clinical studies with S-adenosyl-L-methionine have proven its efficacy in depressive syndrome. S-adenosyl-L-methionine is characterized by a rapid physiological effect and favorable safety profile. S-adenosyl-L-methionine crosses the blood-brain barrier and is involved in the synthesis of CNS neurotransmitters (including serotonin, catecholamines, melatonin, and histamine).
L-methylfolate is a biologically active form of folic acid (vitamin B9). Based on several studies, depression is associated with a decreased serum folate level. L-methylfolate requires no additional transformations in the body and is the only form of folic acid that crosses the blood-brain barrier. Methylfolate plays an important role in the synthesis of major CNS neurotransmitters. L-methylfolate helps relieve the manifestations of depressive syndrome.
Methylcobalamin is one of the active forms of Vitamin B12. Methylcobalamin, at the subcellular level, is much better transported to the organelles of the nerve cells. Because of this feature, it is more effective in improving the psycho-emotional state and normalizing nervous system functioning. People with depressive syndrome have been reported to have a low level of Vitamin B12. Its metabolism is strongly related to folate and SAMe.
DEPRILIUM® contains a scientifically proven combination of natural substances that normalizes the psycho-emotional state by improving the metabolism of neurotransmitters in the brain
Direction for use of Deprilium®
Ingredients: 1 capsule contains: active ingredients:
S-adenosyl-L-methionine 200 mg,
L-methylfolate 0.4 mg, equivalent to 0.4 mg of folic acid,
vitamin B12 in the form of methylcobalamin 250 µg;
excipients: fillers: microcrystalline cellulose, calcium stearate, amorphous silicon dioxide (orisil); capsule shell: gelatin.
Nutritional and energy value (caloric value) per 100 g of dietary supplement: proteins 15.0 g, carbohydrates 1.1 g, fats 0 g; 64.4 kcal / 269.4 kJ.
Nutritional and energy value (caloric value) of daily amount, 2 capsules: proteins 0.13 g, carbohydrates 0.01 g, fats 0 g; 0.54 kcal / 2.26 kJ.
Recommendations for use: DEPRILIUM® is recommended as an additional source of amino acids and vitamins for normalizing the functioning of the nervous system in depressed psychoemotional state, apathy, reduced concentration of attention and performance associated with impaired metabolism of central neurotransmitters (serotonin, noradrenaline, etc.) DEPRILIUM® has neuroprotective properties, improves mood and well-being, increases cognitive functions and performance. DEPRILIUM® compensates for the deficiency of folic acid and vitamin B12 in the body, which contributes to the normalization of the psychoemotional state.
How to use and recommended daily dose: adults should take 1-2 capsules a day 30 minutes before or 1 hour after meals (but not later than 16 hours), while washing down with enough drinking water.
Recommended intake course: 1-3 months. If necessary, the intake course can be adjusted by a physician.
Consult your physician before use.
Do not exceed the specified recommended amount for daily intake.
Do not use it as a substitute for a complete diet.
Contraindications: pregnancy, lactation period, paediatric use, individual intolerance to components, bipolar disorders, malignant neoplasms, blood system diseases.
Dosage form: capsules with a content of 340 mg ± 7.5%.
Storage conditions: store in the original packaging in a dry place, protected from sunlight and out of reach of children, at a temperature from 4 °C to 25 °C.
Date of manufacture: the date of manufacture is indicated on the package.
Shelf life: 24 months from the date of manufacture.
Production batch number: indicated on the package.
Additional information
DEPRILIUM® contains a scientifically based combination of substances of natural origin for the normalization of the psycho-emotional state, by improving the metabolism of neurotransmitters in the brain, which leads to: a decrease in such manifestations as depressed mood, apathy, rapid fatigue, decreased self-esteem, etc.; improved mood and well-being; increased performance and concentration of attention; improved cognitive functions.
S-adenosyl-L-methionine (SAMe) is a substance of natural origin that is present in all cells of the body and is involved in more than 200 metabolic processes. SAMe has a long history of use, including in the European Union and the United States. Numerous clinical studies of S-adenosyl-L-methionine have proven its effectiveness in depressive syndrome. S-adenosyl-L-methionine is characterized by a high rate of onset of physiological effect and a favourable safety profile. S-adenosyl-L-methionine penetrates through the blood-brain barrier, where it is involved in the synthesis of CNS neurotransmitters (in particular serotonin, catecholamines, melatonin, histamine).
L -methylfolate is a biologically active form of folic acid (vitamin B9), which is an important nutrient and is mainly contained in green leaves and vegetables. Folic acid is easily destroyed in the preparation and processing of food; its level in the body is affected by many factors. According to a number of studies, a decrease in serum folate levels is observed in depressions. L-methylfolate does not require additional transformation in the body and is the only form of folic acid that penetrates the blood-brain barrier. Methylfolate plays an important role in the synthesis of major CNS neurotransmitters, amino acids, proteins, and nucleic acids. L-methylfolate contributes to reducing the manifestations of depressive syndrome.
Methylcobalamin is one of the active forms of vitamin B12. Compared to other forms of vitamin B12, methylcobalamin at the subcellular level is better transported into the neuronal organelles. Due to this property, it is more effective for improving the psycho-emotional state and normalizing the functioning of the nervous system. Low levels of vitamin B12 are observed in people with depressive syndrome. Its metabolism is closely related to folate and SAMe; methylcobalamin plays an important role in the metabolism of neurotransmitters. Vitamin B12 is involved in cell division and blood formation, and is crucial for the normal functioning of nerve tissue. Methylcobalamin is responsible for the regeneration and new formation of nerve fibre membranes (also known as myelin membranes) that protect the nerves and ensure the correct and effective transmission of nerve impulse.
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